棋牌大全下载安装

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                          • 当前位置: 代写一篇论文多少钱 > 医学论文 > 支原体感染患者分别采用多西环素与阿奇霉素的疗效对比

                            支原体感染患者分别采用多西环素与阿奇霉素的疗效对比

                            时间:2018-12-18 10:21作者:欧丽滢 陈倩莹 陈茵
                            本文导读:这是一篇关于支原体感染患者分别采用多西环素与阿奇霉素的疗效对比的文章,支原体感染是妇科常见的病症之一,临床表现以泌尿生殖系统炎症反应为主,对女性健康及生活质量均可造成严重影响。通常情况下,该病症的病情较轻,但若病程迁延会加重病情,严重影响女性患者的身心健康。

                              摘    要: 棋牌大全下载安装目的 比较分析多西环素、阿奇霉素治疗支原体感染患者的临床效果,并探究两种药物的应用安全性及不良反应。方法 选取2016年3月~2018年2月妇科收治的48例支原体感染患者,应用数字排序法分成两组。24例患者给予阿奇霉素治疗,设定为对照组;剩余24例患者给予多西环素治疗,设定为观察组。观察比较两组女性患者的临床治疗效果。结果 观察组的总有效率(91.67%)明显高于对照组(75.00%),差异有统计学意义(P <0.05);观察组的腰腹坠痛(95.24%)、外阴不适(95.83%)、泌尿系统症状消失率(95.00%)均明显高于对照组80.00%、79.17%、63.16%,差异有统计学意义(P <0.05);观察组的不良反应发生率(8.33%)明显低于对照组(29.17%),差异有统计学意义(P <0.05)。结论 对支原体感染患者予以多西环素、阿奇霉素治疗,均可获取一定的临床疗效,但多西环素的临床治疗效果显着优于阿奇霉素,该药物的不良反应较少,临床症状恢复效果较好,应用安全性更高。

                              关键词:棋牌大全下载安装 多西环素; 阿奇霉素; 支原体感染; 应用安全性; 不良反应;

                              ZHIYUANTIGANRANSHIFUKECHANGJIANDEBINGZHENGZHIYI,LINCHUANGBIAOXIANYIMINIAOSHENGZHIXITONGYANZHENGFANYINGWEIZHU,DUINVXINGJIANKANGJISHENGHUOZHILIANGJUNKEZAOCHENGYANZHONGYINGXIANG。TONGCHANGQINGKUANGXIA,GAIBINGZHENGDEBINGQINGJIAOQING,DANRUOBINGCHENGQIANYANHUIJIAZHONGBINGQING,YANZHONGYINGXIANGNVXINGHUANZHEDESHENXINJIANKANG[1]。YANJIUZILIAOBIAOSHI,ZHIYUANTIGANRANJIYIYINFAZIGONGNEIMOYAN、SHULUANGUANXINGBUYUNZHENG、GONGJINGYAN、SHULUANGUANYANDENGDUOZHONGBINGZHENG。YINCI,LINCHUANGSHANGXUYAOCAIQUYOUXIAOZHILIAOFANGSHIKONGZHIGAIBINGZHENG,WEINVXINGDESHENGHUOJIANKANGTIGONGBAOZHANG[2]。BENYANJIUJIANGBENYUANFUKESHOUZHIDE48LIZHIYUANTIGANRANHUANZHEFENBIEYUYIDUOXIHUANSU、AQIMEISUJINXINGZHILIAO,ZHIZAIBIJIAOLIANGZHONGYAOWUDELINCHUANGXIAOGUOCHAYIJILINCHUANGYINGYONGANQUANXINGHEBULIANGFANYINGQINGKUANG。

                              1、 资料与方法

                              1.1、 一般资料

                              XUANQU2016NIAN3YUE~2018NIAN2YUEWOYUANFUKESHOUZHIDE48LIZHIYUANTIGANRANHUANZHE,YINGYONGSHUZIPAIXUFAFENCHENGLIANGZU。DUIZHAOZU(n=24):NIANLINGZUIDA56SUI,ZUIXIAO20SUI,PINGJUN(35.74±2.51)SUI;BINGCHENG2~10GEYUE,PINGJUN(3.42±2.45)GEYUE;YIJUWENHUACHENGDUFENWEI2LICHUZHONGYIXIAWENPING(8.33%)、4LIGAOZHONGWENPING(16.67%)、6LIDAZHUANWENPING(25.00%)、12LIBENKEJIYISHANGWENPING(50.00%)。GUANCHAZU(n=24):NIANLINGZUIDA56SUI,ZUIXIAO20SUI,PINGJUN(35.82±2.54)SUI;BINGCHENG2~10GEYUE,PINGJUN(3.46±2.47)GEYUE;YIJUWENHUACHENGDUFENWEI3LICHUZHONGYIXIAWENPING(12.50%)、4LIGAOZHONGWENPING(16.67%)、5LIDAZHUANWENPING(20.83%)、12LIBENKEJIYISHANGWENPING(50.00%)。ZUJIANYIBANZILIAODUIBICHAYIWUTONGJIXUEYIYI(P>0.05),YOUKEBIXING。

                              入选标准:(1)均经血常规、病原学检查、X线检查、血清学检查等常规检查,确诊为支原体感染患者;(2)年龄为20~56岁;(3)均已清楚本次研究的目的,并同意签下知情同意书。
                             

                            支原体感染患者分别采用多西环素与阿奇霉素的疗效对比
                             

                              PAICHUBIAOZHUN:(1)WEIJINGBINGQINGQUEZHEN;(2)HUANYOUYANZHONGZANGQIJIBINGZHE;(3)YOUJINGSHENZHANGAI、YISHIMOHUZHE;(4)HUANYOUQUANSHENXITONGXINGJIBINGHUANZHE;(5)WEIQIANXIAZHIQINGTONGYISHUZHE。

                              1.2、 方法

                              DUIZHAOZUFUYONG0.25 gAQIMEISU(CHANGJIA:HUIRUIZHIYAOYOUXIANGONGSI,PIHAO:GUOYAOZHUNZIH10960167,GUIGE:0.25 g×6PIAN),2CI/RI,LIANFU3 d;GUANCHAZUFUYONG0.1 gDUOXIHUANSU(CHANGJIA:JIANGSULIANHUANYAOYEGUFENYOUXIANGONGSI,PIHAO:GUOYAOZHUNZIH32021266,GUIGE:0.1 g×100PIAN),2CI/RI,LIANFU14 d。DINGZHUHUANZHEZAIFUYAOQIJIANJINZHIXINGSHENGHUO,CAIJIHUANZHEDEGONGJINGFENMIWUJINXINGYAOMINSHIYANYUXIJUNPEIYANG,TINGYAOHOU1ZHOUFANYUANFUCHA,BIJIAOLIANGZUZHIYUANTIGANRANHUANZHEDEZHILIAOXIAOGUO。

                              1.3、 观察指标

                              BIJIAOZUJIANDELINCHUANGLIAOXIAO、LINCHUANGZHENGZHUANGXIAOSHILV(YAOFUZHUITONGXIAOSHILV、WAIYINBUSHIXIAOSHILV、MINIAOXITONGZHENGZHUANGXIAOSHILV)JIBULIANGFANYINGQINGKUANG(EXIN、FUBUBUSHI、FUXIE、TOUHUNFALI)。LIAOXIAOPANDING[4]:LINCHUANGZHENGZHUANGJUNYIXIAOSHI,QUGONGJINGFENMIWUJINXINGZHIYUANTIJIANCE,JIEGUOWEIYINXING,WEIXIANXIAO;LINCHUANGZHENGZHUANGMINGXIANGAISHAN,QUGONGJINGFENMIWUJINXINGZHIYUANTIJIANCE,JIEGUOWEIRUOYANGXING,WEIYOUXIAO;LINCHUANGZHENGZHUANGWUXIANZHEGAISHAN,SHENZHIEHUA,QUGONGJINGFENMIWUJINXINGZHIYUANTIJIANCE,JIEGUOWEIYANGXING,WEIWUXIAO。

                              1.4、 统计学方法

                              JIANGBENCIYANJIUSUODESUOYOUXIANGMUSHUJUZILIAOJUNNARUSPSS 21.0RUANJIANFENXI,JILIANGZILIAOYUJISHUZILIAOFENBIEJINXINGtJIANYANYUχ2JIANYAN,P<0.05KERENWEICHAYIYOUTONGJIXUEYIYI。

                              2、 结果

                              2.1、 临床疗效对比

                              GUANCHAZUDEZONGYOUXIAOLV(91.67%)MINGXIANGAOYUDUIZHAOZU(75.00%),CHAYIYOUTONGJIXUEYIYI(P<0.05)。JIANBIAO1。

                              表1:临床疗效对比[n(%),n=24]
                            表1:临床疗效对比[n(%),n=24]

                              2.2、 临床症状消失率对比

                              GUANCHAZUDEYAOFUZHUITONGXIAOSHILV(95.24%)、WAIYINBUSHIXIAOSHILV(95.83%)、MINIAOXITONGZHENGZHUANGXIAOSHILV(95.00%)JUNMINGXIANGAOYUDUIZHAOZU80.00%、79.17%、63.16%(χ2=10.705、12.688、30.639,P=0.001、0.000、0.000)。JIANBIAO2。

                              表2:临床症状消失率对比(n=24)
                            表2:临床症状消失率对比(n=24)

                              2.3、 不良反应情况对比

                            棋牌大全下载安装   GUANCHAZUYOU1LIEXIN、1LIFUBUBUSHI,WUFUXIE、TOUHUNFALILISHU;DUIZHAOZUYOU2LIEXIN、2LIFUBUBUSHI、1LIFUXIE、2LITOUHUNFALI;GUANCHAZUDEBULIANGFANYINGFASHENGLV(8.33%)MINGXIANDIYUDUIZHAOZU(29.17%),CHAYIYOUTONGJIXUEYIYI(P<0.05)。JIANBIAO3。

                              表3:不良反应情况对比[n(%),n=24]
                            表3:不良反应情况对比[n(%),n=24]

                              3 、讨论

                              ZHIYUANTISHUYUYIZHONGZUIXIAODEWEISHENGWU,KEDANDUSHENGCUNYUXIBAOWAI,SHICUNZAIYUNVXINGSHENGZHIDAOZHONGDEYIZHONGZHENGCHANGJUNQUNZHIYI。ZHIYUANTIGANRANJIBINGZHUYAOJINGXINGJIECHUDENGTUJINGCHUANBO,JUYOUBINGCHENGYINNI、LINCHUANGZHENGZHUANGQINGWEIDENGTEZHENG,XUYAOZAOQIJINXINGJIBINGZHENDUAN,YOUXIAOKONGZHIBINGQINGCAIKEBIMIANBINGQINGJIAZHONG,JIANSHAODUINVXINGSHENTIJIANKANGDEWEIHAI。RUOGANRANFANFU、BINGCHENGQIANYAN,KEYOUFAZIGONGNEIMOYANZHENG、PENQIANGYANZHENG、SHULUANGUANNIANMOYANZHENG,ZUIZHONGZAOCHENGSHULUANGUANDUSAIJIBUYUNZHENG,YEYOUKENENGZAOCHENGYIWEIRENSHEN、ZAOCHAN、LIUCHAN、TAIMOZAOPO,JIKEWEIHAINVXINGSHENXINJIANKANG,YOUHUIDUIJIATINGHEXIEZAOCHENGYIDINGDEYINGXIANG。ZHIYUANTIDEZHUYAOTEZHENGWEIQUEFAXIBAOBI,ZHILIAOGUOCHENGZHONGBUYISHOUβ-NEIXIANANLEIKANGSHENGSUDENGYAOWUDEYINGXIANG。ZHIYUANTIWUFAHECHENGYESUAN,DUIHUANGANLEIDEMINGANXINGBUGAO,JINDUIGANRAODANBAIZHIHECHENGDEBUFENKANGSHENGSUJUYOUJIAOGAODEMINGANDU,RUDAHUANNEIZHILEI、SIHUANSULEIDENGYAOWU[3,4]。

                              AQIMEISUSHIYIZHONGDAHUANNEIZHILEIKANGSHENGSU,KEDUIXIJUNZHUANTAICHANSHENGZUAIZUOYONG,YIZHIXIJUNDANBAIZHIHECHENG,CONGERFAHUIQIYIJUNZUOYONG,YOUQIDUIGELANYANGXINGYANYANGJUN、GELANYINXINGYANYANGJUN、ZHIYUANTIDEKANGJUNXIAOGUOXIANZHE。ZHIYUANTIDUIAQIMEISUDEMINGANXINGJIAOQIANG,GUSHIYONGAQIMEISUZHILIAOZHIYUANTIGANRANKEQUDEJIAOHAODEZHILIAOXIAOGUO。BENYANJIUBIAOMING,GUANCHAZUYUYIDUOXIHUANSUZHILIAO,DUIZHAOZUYUYIAQIMEISUZHILIAO,FAXIANGUANCHAZUDEZONGYOUXIAOLV、LINCHUANGZHENGZHUANGXIAOSHIQINGKUANGYUBULIANGFANYINGQINGKUANGXIANZHEYOUYUDUIZHAOZU。TISHIDUOXIHUANSUDELINCHUANGZHILIAOXIAOGUOXIANZHEYOUYUAQIMEISU,LINCHUANGLIAOXIAOJIAOGAO,LINCHUANGZHENGZHUANGXIAOSHILVGAO,BULIANGFANYINGSHAO,YINGYONGANQUANXINGGENGGAO[5,6]。

                              LINCHUANGZILIAOXIANSHI,NVXINGSHENGZHIQIFASHENGYANZHENGFANYINGZHUYAOYUYIYUANTI、ZHIYUANTI、LINBINGNAISEJUNSANZHONGBINGYUANJUNYOUGUAN,CHUANBOTUJINGYIXINGCHUANBOWEIZHU,QICIYUJIECHUWURANYUANYOUGUAN,RUGONGYONGYUPEN、YIWU、MAOJIN、CHUANGDANDENG。JINNIANLAI,SUIZHERENMENSHENGHUOHUANJINGYUSHENGHUOFANGSHIDEBUDUANZHUANBIAN,ZHIYUANTIGANRANFASHENGLVZHUNIANSHANGSHENG。DABUFENZHIYUANTIGANRANZHEZAIFABINGCHUQIWUDIANXINGZHENGZHUANG,LINCHUANGBIAOXIANYIFUTONGYAOZHANG、YINDAOBUGUIZELIUXUEJIBAIDAIYICHANGDENGZHENGZHUANGWEIZHU,RUOBINGQINGWEIDEDAOJISHIKONGZHI,KEYOUFAGONGJINGYANJIMINIAOXITONGGANRANDENGJIBING。ZHIYUANTIGANRANHUANZHEKOUFUDUOXIHUANSU,GAIYAOWUKEKUAISUBEIRENTIWANQUANXISHOU,YUXUEJIANGDANBAIYOUZHEJIAOGAODEJIEHELV,KEDUIZHIYUANTIGANRANCHANSHENGJIAOQIANGDEYIZHIZUOYONG。BENPINYUAQIMEISUXIANGBI,LINCHUANGYINGYONGANQUANXINGGENGGAO,FUYONGHOUBUYIFASHENGEXIN、FUBUBUSHI、FUXIE、TOUHUNFALIDENGBULIANGFANYING,DUINVXINGGAN、SHENGONGNENGDEWEIHAIXIANGDUIJIAOXIAO。

                              ZONGSHANGSUOSHU,DUIZHIYUANTIGANRANHUANZHEYUYIDUOXIHUANSU、AQIMEISUZHILIAO,JUNKEHUOQUYIDINGDELINCHUANGLIAOXIAO,DANDUOXIHUANSUDELINCHUANGZHILIAOXIAOGUOXIANZHEYOUYUAQIMEISU,GAIYAOWUDEBULIANGFANYINGJIAOSHAO,LINCHUANGZHENGZHUANGHUIFUXIAOGUOJIAOHAO,YINGYONGANQUANXINGGENGGAO,KEZAIZHIYUANTIGANRANLINCHUANGZHILIAOZHONGJIAQIANGYINGYONG。

                              参考文献

                              [1] 王波,陈晓琴.盐酸多西环素与阿奇霉素在围手术期生殖道支原体感染治疗中的应用效果分析[J].中国性科学,2016, 25(11):79-81.
                              [2] 郦爱林.盐酸多西环素联合阿奇霉素治疗女性生殖道支原体感染效果观察[J].现代实用医学,2017, 29(9):1202-1203.
                              [3] 梁丽霞.盐酸多西环素配合阿奇霉素治疗女性生殖道支原体感染临床研究[J].北方药学,2017, 14(6):44-45.
                              [4] 吴胜本,郭建峰,马锐.阿奇霉素治疗孕妇肺炎支原体感染的疗效观察及不良反应监测分析[J].中华医院感染学杂志,2017, 27(16):3761-3764.
                              [5] 克拉霉素与阿奇霉素和多西环素在生殖道衣原体感染患者中的疗效[J].中华医院感染学杂志,2017, 27(17):3856-3859.
                            棋牌大全下载安装   [6] 陈航远,谭其平,蒋宇敏,等.阿奇霉素联合多西环素治疗成人肺炎支原体肺炎的临床分析[J].右江民族医学院学报,2016, 38(5):473-474.

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